At Neurocrine Biosciences, we pride ourselves on having a strong, inclusive, and positive culture based on our shared purpose and values. We know what it takes to be great, and we are as passionate about our people as we are about our purpose - to relieve suffering for people with great needs.
Neurocrine Biosciences is a leading neuroscience-focused, biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs. We are dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, neuroendocrine and neuropsychiatric disorders. The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington's disease, classic congenital adrenal hyperplasia, endometriosis* and uterine fibroids,* as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas. For three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders because you deserve brave science. For more information, visit neurocrine.com, and follow the company on LinkedIn, X and Facebook. (*in collaboration with AbbVie)
As part of the immunology Research Team, the individual will contribute to the assessment of novel therapeutic approaches to target autoimmunity and inflammation in immunology diseases. We are seeking a highly motivated, dedicated and collaborative scientist with knowledge and expertise in cellular and molecular immunology, with experience in antibody/small molecule drug discovery. The successful candidate will work as part of a highly team-oriented and collaborative group. The focus of this position will be to support the progression of multiple drug discovery projects in the Neuroimmunology space, by independently designing, performing, and validating key in vitro cell-based functional assays. The candidate will also perform experiments to understand the mechanism of action of drug candidates, and present data to cross-functional teams.
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Designing and performing experiments to support scientific activities and project goals
Separation of human PBMC from whole blood or leukopak, as well as the isolation of primary human leukocyte populations (T cells, CD4+ T cells, DCs) for downstream assays
Maintain cell lines and primary cell cultures
Perform immunological assays including lymphocyte proliferation, activation, cytokine secretion, and differentiation
Perform basic molecular biology assays, including mRNA isolation, Taqman qPCR
Flow cytometric analysis of immune cell subsets and analysis of data
Perform immunoassays (MSD, ELISA, etc) for analysis of soluble proteins in cell supernatants/murine plasma
Maintains and updates SOPs and electronic lab notebook and writes data summaries for experiments conducted
Present data and findings to cross-functional project teams
Provides training and/or supervision to junior staff, as needed
Other duties as assigned
BS/BA in degree in biology, molecular and cellular immunology, or a related biological area and 2+ years of relevant experience OR
MS/MA degree and industry experience preferred, immunology degree/background preferred OR
PhD degree and relevant experience, industry experience preferred, immunology degree/background preferred
Robust experience with whole blood, PBMC, T cells, and immune cell-based in vitro assays, hands-on experience in Treg assays is a plus
Experience in RNAseq and data analysis independently is a plus
Expertise in cell culture and aseptic technique, involving both immortalized cell lines and primary human/murine cells
Experience in immunoassays (ELISA, MSD) and molecular biology techniques (mRNA isolation, qPCR)
Experience with multicolor flow cytometric analysis and multiplex MSD is a must to have
Able to explain the process behind data generated and the implications of the results
Strong knowledge of one or more scientific disciplines, especially immunology
Strong knowledge of scientific principles, methods, and techniques, and demonstrated ability to work with a variety of laboratory equipment/tools
Excellent communication, problem-solving, and analytical thinking skills
Ability to work as part of a cross-functional team, and present data and concepts clearly and concisely
Demonstrated ability to meet multiple deadlines with a high degree of accuracy and efficiency, and experience prioritizing multiple projects is a plus
The pay you should reasonably expect to receive is $43.17 - $62.55 per hour. Decisions depend on various factors, such as primary work location, complexity and responsibility of role, job duties/requirements, and relevant experience and skills.
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Neurocrine Biosciences is an EEO/Disability/Vets employer.
We are committed to building a workplace of belonging, respect, and empowerment, and we recognize there are a variety of ways to meet our requirements. We are looking for the best candidate for the job and encourage you to apply even if your experience or qualifications don’t line up to exactly what we have outlined in the job description.