We are seeking a Sr. Technical Product Manager to lead the strategy and execution of data product, AI/ML system, AI-powered tooling, and automation initiatives across the go-to-market and operational teams embedded within Natera’s core business units (i.e., Oncology, Women’s Health, Organ Health), including Sales, Marketing, and Medical stakeholders.
This role focuses on building, scaling, and leveraging platforms and products that power decision intelligence and activity orchestration across these domains. You will work in close collaboration with ‘S&M + GM’ leaders while building through centralized Data & AI organization platforms, standards, and governance. You will own the full product lifecycle from discovery through production, ensuring solutions are adopted, trusted, and deliver measurable business impact. In doing so, you will work hands-on as an empowered builder of AI and software solutions to improve workflow efficiency, productivity, and quality for the teams you support.
This is a technical product role requiring fluency in data systems, modern data platforms, ML, and AI implementation patterns (and the ability and drive to build with them directly), combined with strong experience and stakeholder intuition across Sales, Marketing, Medical, and related functions.
This role sits at the intersection of business impact and technical depth, with deep visibility into commercial performance and executive decision-making. You will have direct ownership of high-impact initiatives fueling overall organizational success.
What You’ll Do
Strategy & Roadmap
Define and own the Data & AI product strategy and roadmap for the S&M + GM pod by deeply partnering with business leaders to proactively identify high-impact opportunities, shape problem definitions, and drive aligned priorities
Translate ambiguous business problems (e.g., churn risk, campaign performance, clinical profile segmentation, next-best-action orchestration) into clear product direction and measurable outcomes
Own the line between ‘what the business needs’ and ‘what gets built’ end-to-end
Discovery, Experimentation, & Requirements
Develop deep context on the domain so you can proactively propose solutions rather than field requests
Be hands-on with data: query datasets, review schemas, and validate assumptions through analysis
Lead end-to-end product discovery with interviews, workflow mapping, data assessments, ROI modeling, etc.
Define clear product requirements (PRDs, user stories, acceptance criteria) and success metrics
Design and run experiments to validate product performance and measure causal impact
Establish leading indicators and KPIs for proactive product and process health assessments
Delivery, Data, & ML Lifecycle
Partner with data and AI/ML engineering resources to deliver scalable products and capabilities
Guide development of robust data pipelines and unified data models (360° views across key entities)
Own the end-to-end ML lifecycle: feature definition, evaluation, deployment, monitoring, drift detection, and retraining
Ensure training–serving consistency, model versioning, and clear deployment decision gates
Establish strong observability across data pipelines and models (data quality, latency, reliability, cost)
AI Productization & Hands-On Building
Define and implement AI product patterns, including agentic workflows and tool/function-calling integrations
Build process automations and internal tools that improve workflow efficiency, productivity, and output quality for the teams you support
Establish evaluation frameworks for LLM-powered features (faithfulness, relevance, safety, cost, latency)
Implement prompt strategies, guardrails, and continuous evaluation pipelines
Governance, Compliance, & Data Quality
Ensure products meet regulatory and compliance requirements
Champion data quality, lineage, and reliability through data contracts and observability standards
Partner with governance teams (Security, Legal, Compliance, AI Governance) to operationalize AI responsibly
Adoption, Change Management, & Impact
Launch products with supporting enablement activities to ensure solutions are embedded in workflows with confidence
Partner with stakeholders to integrate products into proactive, day-to-day decision-making
Monitor product usage, performance, and business outcomes to iterate based on data and feedback
Quantify and communicate impact (e.g., revenue lift, cost reduction, cycle time improvements, forecasting accuracy)
Influence across Sales, Marketing, Medical, and GM stakeholders through delivery, not authority
Qualifications
Required
7+ years of relevant experience (e.g., product management, applied AI/ML engineering, technical founder, forward-deployed engineering), including 3+ years building data products, AI/ML systems, or related platforms
Demonstrated domain fluency in Sales, Marketing, Field Medical, and/or related commercial/GTM functions
Strong understanding of sales funnel, marketing funnel, medical affairs funnel, and related funnels to relate product ideas to the overall opportunity landscape
Familiarity with key domain-relevant tooling (e.g., Salesforce) and associated data
Familiarity with modern data stacks (e.g., Snowflake, dbt, AWS/SageMaker, Airflow/Dagster)
Strong stakeholder leadership and communication skills, with the ability to work across technical and business teams
Experience working in regulated environments (e.g., healthcare, life sciences, fintech)
Preferred
Experience in healthcare, diagnostics, life sciences, and/or digital health
Familiarity with healthcare data domains and systems
Experience with vendor evaluation, platform selection, or external AI tooling ecosystems
Advanced degree in a technical and/or business discipline
What Success Looks Like
Production-grade data and AI products are deployed and embedded in day-to-day decision-making workflows
Process automations and internal tools you build are reducing manual effort and improving output quality across the teams you support
Measurable improvements seen in key business metrics (e.g., increased sales efficiency, better campaign performance)
Reliable, high-quality data foundations connect patient, clinical, financial, and commercial insights end-to-end
AI systems are continuously monitored, evaluated, and improved with measurable business impact
Stakeholders trust and adopt implemented solutions across both corporate and business-unit teams
Internal teams have transparent access to the function’s roadmap, trust in delivery against it, and visibility into the evaluation logic that prioritizes initiatives based on their impact to organizational goals
The pay range is listed and actual compensation packages are based on a wide array of factors unique to each candidate, including but not limited to skill set, years & depth of experience, certifications and specific office location. This may differ in other locations due to cost of labor considerations.
Remote USA
$140,600—$175,700 USD
OUR OPPORTUNITY
Natera™ is a global leader in cell-free DNA (cfDNA) testing, dedicated to oncology, women’s health, and organ health. Our aim is to make personalized genetic testing and diagnostics part of the standard of care to protect health and enable earlier and more targeted interventions that lead to longer, healthier lives.
The Natera team consists of highly dedicated statisticians, geneticists, doctors, laboratory scientists, business professionals, software engineers and many other professionals from world-class institutions, who care deeply for our work and each other. When you join Natera, you’ll work hard and grow quickly. Working alongside the elite of the industry, you’ll be stretched and challenged, and take pride in being part of a company that is changing the landscape of genetic disease management.
WHAT WE OFFER
Competitive Benefits - Employee benefits include comprehensive medical, dental, vision, life and disability plans for eligible employees and their dependents. Additionally, Natera employees and their immediate families receive free testing in addition to fertility care benefits. Other benefits include pregnancy and baby bonding leave, 401k benefits, commuter benefits and much more. We also offer a generous employee referral program!
Natera is proud to be an Equal Opportunity Employer. We are committed to ensuring a diverse and inclusive workplace environment, and welcome people of different backgrounds, experiences, abilities and perspectives. Inclusive collaboration benefits our employees, our community and our patients, and is critical to our mission of changing the management of disease worldwide.
All qualified applicants are encouraged to apply, and will be considered without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, age, veteran status, disability or any other legally protected status. We also consider qualified applicants regardless of criminal histories, consistent with applicable laws.
If you are based in California, we encourage you to read this important information for California residents.
Please be advised that Natera will reach out to candidates with a @natera.com email domain ONLY. Email communications from all other domain names are not from Natera or its employees and are fraudulent. Natera does not request interviews via text messages and does not ask for personal information until a candidate has engaged with the company and has spoken to a recruiter and the hiring team. Natera takes cyber crimes seriously, and will collaborate with law enforcement authorities to prosecute any related cyber crimes.
