Principal Engineer, Technical Development

Cross Functional Collaboration

• Work closely with Quality, Supply Chain, and Manufacturing Operations to ensure seamless technology transfer and scaleup.
• Guide technical teams through engineering design reviews, process risk assessments, and regulatory submissions, fostering a culture of innovation and technical excellence.

Operational Excellence

• Drive continuous improvement initiatives using Lean, Six Sigma, and advanced process analytics.
• Troubleshoot complex manufacturing challenges and implement robust, sustainable solutions.
• Ensure compliance with cGMP, safety standards, and global regulatory requirements.

Education and Skills Requirements:

• Bachelor’s degree in chemical or similar engineering discipline with minimum of 7 years relevant experience; advanced degree MS or PhD preferred
• Proven track record designing, implementing, and scaling manufacturing systems
• Hands-on approach for operation of and troubleshooting manufacturing skids
• Development and implementation of PAT technologies
• Experience overseeing outsourced activities at CDMOs
• Expertise in process modeling, control systems, automation, and PAT.
• Experience in Biologics Downstream Purification Process Development and/or Bioconjugation Development preferred
• Familiar with the concepts of Scale-Down Model Qualification (SDMQ), Process Characterization, and defining Process Control Strategy (PCS)
• Strong understanding of current Good Manufacturing Practices (cGMP) and regulatory frameworks (FDA, EMA, ICH) relevant to continuous manufacturing of biologics.
• Attention to detail, exceptional communication skills, and the ability to influence all levels of the organization.

MA Pay Range

$147,000—$180,000 USD

The pay range reflects the base pay range Dyne reasonably expects to pay for this role at the time of posting. Individual compensation depends on factors such as education, experience, job-related knowledge, and demonstrated skills.

The statements contained herein reflect general details as necessary to describe the principles functions for this job, the level of knowledge and skill typically required, and the scope of responsibility, but should not be considered an all-inclusive listing of work requirements. Individuals may perform other duties as assigned, including work in other functional areas to cover absences or relief, to equalize peak work periods or otherwise balance workload.

Dyne Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.