Alpine Immune Sciences, Inc.

Alpine Immune Sciences, Inc. was a clinical-stage biopharmaceutical company headquartered in Seattle, Washington, focused on discovering and developing innovative, protein-based immunotherapies. Established in 2015, the company advanced multiple product candidates into clinical trials for inflammatory/autoimmune diseases and cancer. Their scientific platform consisted of unique protein engineering strategies, including the directed evolution of immune proteins into novel, multi-targeted therapeutics. Alpine's mission was to improve patient outcomes by developing therapies that modulate the human immune system.

Alpine had a diverse pipeline of multi-targeted therapies, including acazicolcept (ALPN-101) and povetacicept (ALPN-303). Acazicolcept is a first-in-class dual inhibitor of the CD28 and ICOS T-cell costimulatory pathways, while povetacicept is a dual antagonist of BAFF and APRIL, cytokines that play key roles in the pathogenesis of multiple autoimmune diseases. However, in January 2024, Alpine Immune Sciences was acquired by Vertex Pharmaceuticals.

Alpine Immune Sciences provides its employees with the flexibility to work onsite, remotely, or via a hybrid schedule. This approach, which prioritizes the health and safety of employees, allows for a dynamic work environment with state-of-the-art collaboration tools, premier lab and office spaces with inspiring views, and an open design to facilitate teamwork.

Alpine Immune Sciences provides a competitive benefits package for its employees, including premium medical, dental, and vision coverage for employees and their dependents. They also offer flexible paid time off, a 401(k) plan with company match, and competitive salaries with equity participation in the form of stock options. They believe in fostering a healthy work-life balance and provide a robust wellness program to support the physical, mental, and emotional health of their employees.

Alpine Immune Sciences is a clinical-stage biopharmaceutical company focused on discovering and developing novel protein-based immunotherapies. Their mission is to improve patient outcomes in inflammatory and autoimmune diseases and cancer by leveraging their unique protein engineering platform. This platform utilizes directed evolution to create multi-targeted therapeutics that modulate the human immune system, potentially leading to more effective and safer treatments for patients.

Alpine Immune Sciences fosters a culture of collaboration, innovation, and agility. They encourage their employees to think outside the box, work together, and be adaptable in the face of challenges. They value diverse perspectives and create a safe, respectful, and inspiring environment where everyone feels heard and empowered to reach their full potential.

Alpine Immune Sciences is committed to building a diverse and inclusive organization where everyone feels valued and has a voice. They strive to create a safe and respectful environment where employees can bring their authentic selves to work, fostering collaboration and innovative thinking. They are actively working to increase diversity in their team and champion inclusion by advocating for underrepresented groups, listening to colleagues with respect, promoting equal footing for all employees, and fostering active learning about unconscious bias and uneven power structures.